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A drama based on Terry Gilliam's 1995 sci-fi adventure begins when a time traveler from the post-apocalyptic future arrives in the year 2015 on a mission to save mankind from a deadly plague that will eventually decimate 93.6% of the human race.

Cole's search for information about a mysterious organization known as the Army of the 12 Monkeys leads him to a mental institution in 2015, where there's a patient who holds the key to the plague that will destroy the world. Meanwhile, Dr. Railly risks her life and disrupting the course of history to help Cole.

Cole's search for the location of the virus leads him to 2014, and to a devastating moment in Dr. Railly's life involving a dangerous outbreak in Haiti.

A fight for the future ensues when a dangerous band of marauders hunting for Cole and Ramse threaten the mission to save the past.

Cole and Dr. Railly battle the Army of the 12 Monkeys after they both discover the Night Room, an off-site, black ops lab that houses the virus that will one day destroy the world.

Cole risks his future to save Dr. Railly after the tragic events of the Night Room create an alternate reality in 2043.

Cole, Railly and Aaron race to stop the virus from being deployed as a bioweapon in Chechnya.

To rescue Cole from the past, Dr. Jones must convince a former ally that her mission is worth saving.

Cole finds himself in 2017 at the height of the plague. Out of options, Jones faces an impossible choice to replace the Core.

Forces comes to a head when Ramse does what it takes to protect his newfound family, leaving Cole to deal with the aftermath.

Cole's last-ditch effort to stop the Army of the 12 Monkeys brings him to Tokyo in the year 1987.

Railly searches for the one person who can save Cole as the effects of time travel take a deadly toll on his body.

In the Season 1 finale, Cole and Railly attempt a final confrontation with their closest enemies, while Jones faces a new threat to all that she has accomplished.