Dylan and Lizzie are unable to identify a motive or connection when several average people blow themselves up using suicide bombs. Also, Julian, concerned that Dylan could be exposing himself to past enemies, enlists Lizzie to talk him out of hiring Ashley, a publicist.
Leroy decides to bring in a psychic to help The Bureau figure out who bugged their office. While he and the rest of the team are determined to make something of the findings so that they can reclaim the office from Merv, Max refuses to give in to the superstitions.
With Waystar's stock plunging to dangerous lows, Kendall is confronted with a major crisis involving a secret bank debt. Upset with Marcia for pulling rank in the Roy apartment, Shiv decides to enlist an old paramour to conduct a background check on Logan's third wife. Kendall and Roman attend their first big meeting in their new roles, as do Tom and Greg. Kendall tries to convince Rava to give their marriage a second chance, and gets an unexpected reaction to his handling of Waystar from his father.
Sunny and Bajie arrive at Pilgrim's Fortress, only to face an angry M.K.; The Widow enlists Gaius; Moon and Lydia rally the troops.
Supergirl learns the true depth of Serena's nefarious plans for Earth. Supergirl, Mon-El and Alura must devise a plan to stop her before Serena gets to Earth. J'onn prepares to say goodbye to his father.
Holmes and Watson's search for the killer of a woman found encased in cement takes them inside the clean technology industry. Also, Watson takes a giant leap forward regarding her interest in adoption,
Clarke and Bellamy make a startling discovery about Wonkru's battle plans as Echo risks her friendship with Raven to complete her mission.
As Vincent, Marcel and Josh work to clean up the city, an uprising of purist vampires leads the supernatural factions into a deadly showdown. Hope's attempt to bring her family back together leaves her struggling with the consequences. Finally, Freya makes a life-changing decision.
Drummer and Ashford find themselves trapped with few options for survival; Anna tends to the wounded masses as Melba continues to hunt down her prey; the Rocinante crew struggles to survive as Naomi reunites with her true family.
Alexis's former partner Oliver Hill resurfaces and warns Mara that Reverie 2.0 has some dangerous side effects. Back at Onira-Tech, a BCI is stolen and Mara must go into a rogue Reverie.
Max is brought to Angels Memorial with breathing difficulty, and Ariel tells him she loves him. Also, Rox accompanies Willis and Martin to the funeral of an army buddy of Willis' brother, and Willis decides to get to the bottom of what happened to his brother's unit.
Stanley and Anatole's true colours put Laura and her family directly in harm's way. With Mia speaking at the commission, Laura must do everything in her power to stop an awful attack. Leo and Mattie return to the Elster house where Leo comes to understand a painful truth, but Mattie has a secret that could knock their fledging relationship off course. Niska continues her mysterious journey that takes her to Wales, where she must defy all her instincts to survive.
Tandy and Tyrone come face-to-face as the two are able to sit down and talk. Having not been able to tell anyone else what they have been experiencing, both take the opportunity to finally confide in the one person who may truly understand what they are going through. Meanwhile, Otis reveals a secret side of himself and Greg seems to be onto something with Melissa's case against Roxxon.
Team Splinter goes back in time to the wild frontier in search of a weapon to destroy the Witness.
The team is tasked with protecting a scientist who has developed a deadly technology that, in the wrong hands, could have devastating consequences to mankind. Meanwhile, Ryan and Shelby stumble on something personal of Alex's that signals a possible change in her personal life.
The team infiltrates a Nazi gala to steal an artifact known as "Die Glocke"; their operation comes undone when French Resistance interferes and an unexpected guest arrives.