In the Season 2 premiere, the Pazzis strike, leaving the fate of Florence in Leonardo's hands, while Riario forges on in his quest to attain the Book of Leaves.
Leonardo uses his wiles to restore order to Florence, while Pope Sixtus recruits powerful allies and Nico tries not to succumb to Riario's temptations.
Leonardo's quest for the Book of Leaves continues; Pope Sixtus deals aggressively with Florence, leaving Lorenzo to make sacrifices; and Lucrezia undertakes an alliance-forming mission to Rome.
Leonardo attempts to navigate the Atlantic without maps; Lucrezia is snuck into the Vatican for a vital meeting; and Lorenzo is recognized on his way to Naples.
Leonardo, Riario and Nico are reunited in the New World; Lorenzo is helped by an old flame in his attempt to save Florence; and Clarice's hold on the Medici bank is threatened.
Leonardo and Riario are challenged upon entering the Vault of Heaven; Lorenzo participates in King Ferrante's bloody games; and Lucrezia encounters the Turk on her way to Constantinople.
Leonardo and his allies' quest for the Book of Leaves turns deadly; Carlo comes to Clarice's aid; and in the East, the son of the Sultan is intrigued with Lucrezia.
Leonardo and Riario face death, while Zoroaster and Nico plot an escape. Meanwhile, Lorenzo cools his heels waiting for an audience with the King of Naples; and Bayezid comes to Rome on a diplomatic mission.
Back in Florence, Leonardo finds an iron-fisted Duke Federico ruling his subjects; a sinful Riario seeks redemption; and King Ferrante enters negotiations with Lorenzo.
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