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Chuck Bartowski is a computer geek that gets catapulted into a new career as the government's most vital secret agent. When Chuck opens an e-mail subliminally encoded with government secrets, he unwittingly downloads an entire server of sensitive data into his brain. With the government's most precious secrets in Chuck's head, Major John Casey of the National Security Agency assumes the responsibility of protecting him. His partner is the CIA's top agent, Sarah Walker.
As Chuck Bartowski continues to come to grips with his newly adopted life as a spy, tension builds between his recently appointed partners Sarah Walker and John Casey. When a doctor who seems to have a solution to Chuck's problem is killed, Casey and Walker turn the blame at one another. Both agents persistently try to convince Chuck that the other one is responsible and now it is up to Chuck to decide which one to trust. Who will he choose?
Chuck Bartowski is finding out that living two separate lives is not going to come easy. After being challenged by his boss at Buy More, Chuck needs the help of his best friend Morgan and the Nerd Herd, to prove that he is up to the task and ready to become assistant manager. Meanwhile, Sarah and John force Chuck to go undercover for his first real spy mission. It seems that Chuck's two different lives are learning to Tango, but which one will learn to take the lead?
Chuck faces an unusual task, when Sarah's hot colleague from the CIA shows up requesting help for a mission. Morgan tries to get Chuck to set him up with Sarah's new friend. When Chuck finds out that a million dollar diamond hidden in a Malibu mansion is being used to help fund terrorists, he must help these two beautiful women steal it back. Chuck is finding out that Sarah's job of living a double life, which she is all too good at, is really preventing him from getting to know who she really is.
Chuck faces his first moral dilemma as a spy. When agents Sarah and Casey refuse to help an unauthorized mission that is taking place in Chinatown by a top Chinese spy, Chuck is faced with a tough decision. Either go against the U.S. government and his friends, or do what he believes is right? Meanwhile, Morgan is caught in a dilemma of his own when Buy More forces him into a sales competition that could cost him his job.
Chuck accidentally runs into a fellow government agent who seems to be living a similar life. It turns out this agent is a gadget whiz, whose brain makes him a national security asset and a dangerous liability, much like Chuck. Chuck faces a predicament whether he should help turn this agent into Sarah and Casey or help this agent escape his handlers. Meanwhile, Halloween, a holiday that means a lot to Chuck and Morgan as buddies, proves to be a little different this year as Morgan feels that Chuck is neglecting both their childhood and friendship.
Chuck has to return to Stanford University, the institute that expelled him, on homecoming weekend to help a former professor. Chuck finds out that his former professor is also a government operative who is being hunted out for a sensitive top-secret file. Chuck must use his past experiences to find his Professor's hidden secret, while at the same time discovering shocking secrets about his own life. More importantly, Chuck discovers the truth about his former friend, Bryce Larkin, the one who got him kicked out of Stanford. Meanwhile, Morgan has problems with the new assistant manager at Buy More.
Chuck battles with his cover love life and real love life when he meets a very pretty girl named Lou, who seems interested in the real Chuck. On the other hand, his relationship with Sarah heats up as they go on a double date with Ellie and Captain Awesome and try to explain their sex life. Meanwhile, a poison specialist is trying to obtain codes to nuclear facilities and is using a "truth" poison to help get his answers. After all are exposed to the truth, Chuck soon discovers a lot about his partners.
Chuck starts dating Lou, a sandwich maker, and things seem to be going really well. This incites some jealousy on the behalf of Chuck's ex-girlfriend, Sarah, as she may be discovering that her feelings were not all just a cover. However, things seem to get complicated when Lou is discovered to be a part of a smuggling group. Is the relationship with Chuck another phony or is this relationship for real? Meanwhile, Morgan starts developing a new relationship with an unlikely girl.
It's Thanksgiving and Chuck's nemesis, Bryce Larkin, returns to his life after being ruled dead earlier in Chuck's life. Secret internal committees trying to destroy the intersect, now better known as Chuck's brain, saved Bryce in hopes he would be able to help them locate it. Bryce needs Chuck to help prove to Sarah, Casey and the rest of the CIA that he is not rogue. Upon seeing Bryce and Sarah back together, former lovers and partners, Chuck grows jealous and doubts any future with Sarah. Meanwhile, Buy More is prepping for the biggest shopping day of the year and Morgan is left in charge to ensure all runs well.
Still licking his wounds after realizing Sarah continues to have feelings for Bryce, Chuck must assume the cover of being Sarah's husband on a mission to foil a politically connected counterfeiter and yachtsman. Emotions and sea legs are tested when Chuck, Sarah and Casey have to head to the marina to scuttle a plot that also puts an unwitting Morgan and Anna squarely in the crosshairs. Meanwhile, It's time for the annual Buy More holiday party, but the party comes with lots of rules from Big Mike.
Chuck discovers that many Russian arms dealers are secretly meeting in Los Angeles. One particular Russian woman catches his attention, and he flashes on her as being Agent Casey's ex-girlfriend. Chuck grows very intrigued and begins to pester Casey about their history. After learning this woman is to set marry one of the Russian arms dealers, Chuck insists that Casey fights for his woman. Will Casey fight for his true love without compromising his identity? Meanwhile, Captain Awesome and Ellie reach a tough point in their relationship.
Captain Awesome asks Chuck if he can have Ellie's hand in marriage, and then insists Chuck holds on to the ring until he plans it all out. Chuck decides to lock it in his Buy-More locker, and returns the next day to discover everything had been stolen from the store. Meanwhile, Agent Casey and Agent Walker discover that the CIA has been spying on them in hopes of discovering "the intersect." With Chuck's identity and life on the line, NSA has no other option than to relocate Chuck into a permanent holding cell. Will Chuck lose his family and friends forever?
Chuck prevents Colt from obtaining the Cipher -- a device that would ultimately lead to a new Intersect. Chuck is told that this successful mission marks the end of his espionage career and the beginning of a normal life. Free from bullets and bombs, Chuck finally asks Sarah out on a real first date. But Chuck's role as the old Intersect is not good news for everyone as Casey deals with a difficult order assigned to him. Meanwhile at Buy More, Morgan devises an eccentric way to hire a new assistant manager.
Chuck must go undercover to retrieve the Cipher from the Black Widow. But in order to get close to his target, Chuck must learn the art of seduction from the suave and sophisticated Roan. Unfortunately for Chuck, Sarah and Casey, Roan is no longer the world's greatest spy. Meanwhile, Morgan offers Captain Awesome some advice for a romantic night with Ellie, and Lester struggles to gain respect at Buy More as the new assistant manager.
Chuck is overcome with jealousy when his nemesis Bryce Larkin -- and Sarah's ex-lover and partner -- makes an unexpected return. Chuck and Sarah's growing feelings for each other are tested when their latest mission requires Sarah and Bryce to pose as an extremely affectionate couple. Meanwhile, Morgan faces his own challenge at Buy More when he must deal with a gang of bullies, from a neighboring sporting goods store in the strip mall called, the Mighty Jocks led by the fearful Mitt.
Chuck learns more about Sarah's past when they run into her old high school nemesis Heather Chandler. Sarah's teenage insecurities come to surface and she tries to avoid Heather at all costs. Chuck, on the other hand, does everything he can to hear more about Sarah's hidden life. When Heather's nerdy husband Mark turns out to be a key player in a new mission, the agents must attend Sarah's high school reunion to prevent the sale of potentially dangerous super-bomber plans -- all the action ends with the ultimate cat fight. Meanwhile, Big Mike leaves town for a day and Buy More's new assistant manager Lester decides to implement a new sales policy.
Life in espionage takes its toll on Chuck and everyone is taking notice. Chuck tries to explain his unusual behavior to Ellie and to the quirky Buy More efficiency expert Emmett Milbarge, but a new assignment only complicates things. After a global terrorist comes searching for Jeff, Chuck is forced to socialize with Jeff in order to find out what role the oddball plays in the mission. Sarah, Casey and Chuck are all shocked when they discover that the fate of the world and the prevention of World War III rest in Jeff's hands.
Chuck runs into his ex-girlfriend Jill while on a Nerd Herd call. In an attempt to save face, he lies to the girl who broke his heart and tells her that he is more successful than he really is. When Chuck flashes on Jill's boss - a research scientist who may have developed a deadly bio-weapon, he, Sarah and Casey must find out if Jill is involved. Meanwhile at the Buy More, Big Mike nearly chokes to death, which leads company efficiency expert Emmett to implement a mandatory CPR course taught by Captain Awesome.
Chuck and Jill are enjoying the honeymoon stage of their rekindled relationship. The two lovebirds plan a weekend getaway but have to cancel at the last minute when Casey and Sarah inform Chuck that he is needed for an immediate mission to find corrupt agents in the CIA. Jealousy erupts when Jill finally meets Sarah and learns that Chuck and his handler must pose as a couple. Chuck does his best to reassure Jill that his relationship with Sarah is purely business but only finds himself in more trouble when his mission does not go as planned. Meanwhile, corporate efficiency expert Emmett is out to get Chuck and interrogates Morgan to get some dirt on his best friend.
Chuck, Sarah and Casey make a shocking discovery about Jill. In the wake of his disbelief, Chuck is asked to find an agent called Leader and he willingly agrees. Meanwhile, Captain Awesome's parents are coming for Thanksgiving and Ellie is determined to have the perfect Thanksgiving dinner. To make sure everything goes smoothly, she tells Morgan that he cannot come to dinner this year. Without any holiday plans to fall back on, Morgan is recruited by Big Mike to stand guard at the Buy More with Lester and Jeff.
Chuck is still reeling from his relationship with Jill and is sent on a mission to take his mind off her. Casey gets a shock of his own when he finds out that his sensei Ty Bennett, who taught him everything he knows, is now one of the most wanted rogue agents. While on the search for Bennett, it becomes clear that Casey may be too emotionally involved to continue with the mission. Meanwhile, Awesome's parents Honey and Woody make a surprise visit to help Ellie and Awesome plan their wedding. At the Buy More, Emmett reinstates the employee of the month contest, but Morgan, Jeff and Lester have other plans.
Chuck spies on Sarah and sees her on a date with an older man. Chuck frantically tries to warn Sarah after he has an Intersect flash, but she assures Chuck that she is not in danger and reveals the identity of the mystery man. Meanwhile, Anna wants to move into an apartment with Morgan forcing him to finally act like an adult. Awesome offers to help Morgan pay for the apartment, but a relic from the past causes Morgan to lose focus on his new grown-up responsibilities.
Christmas Eve does not go as planned when an amateur criminal on the run from the police crashes into the Buy More and takes Chuck, Ellie, Awesome and the rest of the Buy More gang hostage. In order to protect Chuck's cover and the safety of the other hostages, Sarah and Casey secretly go in to the store to remove Chuck, but the mission quickly falls apart when Chuck refuses to leave his friends and family behind.
Chuck foils a plan to kill international rock star Tyler Martin leading Sarah and Casey to kidnap the musician to find out who wants him dead. When Chuck is left unattended with Tyler, the party animal rocker convinces Chuck to go out on the town, which only ends in a night of trouble. Meanwhile, Big Mike enlists Morgan to look out for his old football buddy Jimmy who was just released from jail and hired at the Buy More. In the midst of Morgan's newly assigned duties, he wins a pair of backstage passes to Tyler's show and holds a contest in true Super Bowl fashion that pits Jeff against the formidable ex-con Jimmy.
Chuck and Sarah's latest assignment forces them to pose as a happily married couple living in the suburbs. They meet some interesting characters including Brad, a cheerful next-door neighbor in the stationary business, and Sylvia, a seductive and attractive woman who lives across the street and has her eye on Chuck. Meanwhile, Big Mike is on a work rampage after his wife files for divorce, so the Buy More gang sets him up on a dating website to keep him distracted.
Chuck helps a heartbroken Morgan spy on Anna. After he flashes on Anna's new boyfriend, Chuck, along with Sarah and Casey, is sent to discover his connection to a dangerous gang. Meanwhile, Jeff and Lester try to convince Ellie and Awesome to hire their band Jeffster! for the wedding.
Chuck breaks up with Sarah after Ellie's urging, but jealousy strikes when Sarah must seduce a handsome agent in order to retrieve Fulcrum intelligence. Morgan deals with his mother's relationship with Big Mike by crashing at Chuck's apartment much to Ellie and Awesome's chagrin. Meanwhile, Jeff and Lester talk their way into hiring the new Buy More employee but decide to search for the "Buy More Babe."
Chuck, Sarah and Casey learn about a man called "Perseus" who is behind Fulcrum's plans to build their own Intersect. While Sarah and Casey are sent to find Perseus, Chuck and Agent Cole Barker are forced to stay in a safety bunker. When the mission takes a dangerous turn, their orders to stay out of harm's way go out the window. Meanwhile, Morgan tries to convince Anna that moving in with him would be a bad idea.
After Chuck is contacted by the mastermind behind the Intersect Computer, he must decide who he can trust; Sarah and Casey or the mysterious scientist who might be able to erase the Intersect from his mind. Meanwhile, a conflict breaks out between the Burbank Buy More and the more prestigious Beverly Hills branch.
When Chuck expresses his feelings about his complicated relationship with Sarah, a heartless female agent named Alex Forrest is sent to evaluate Sarah's performance as Chuck's handler. Morgan, Jeff and Lester try to weasel their way into getting invited to Awesome's bachelor party.
Chuck's life seems to be coming together: his long-absent father Steve has returned and he's landed his dream job with his hero Ted Roark. Unfortunately for Chuck, neither turns out to be quite what he expected.
After Chuck's father Steve is kidnapped by Fulcrum, Chuck learns the only chance he has to find him is by putting his trust and life into the hands of the person he trusts the least; his ex-girlfriend Jill Roberts. Meanwhile, the Buy More team tries to sabotage Emmett's corporate evaluation.
When Chuck and Sarah go AWOL to rescue Chuck's father Steve, they discover that spending time together without any surveillance allows for unchartered chemistry. But as the two get closer, Casey zeroes in on their hidden location. Meanwhile, Morgan becomes the pariah of the Buy More after mistakenly getting Emmett promoted.
When Ellie and Awesome's wedding day finally arrives, Chuck must save Ellie's life and her big day from being ruined by Ted Roark and Fulcrum.
As the upgraded Intersect, Chuck trains to become a full-fledged spy but hits rock bottom when he flunks out of spy school and loses Sarah in the process. Meanwhile, Morgan comes home from Benihana School to help Chuck get over Sarah.
Chuck gets a new mission when Sarah's best friend Carina comes through town with her fiancé Karl. Things get complicated when Chuck wants to hash out his and Sarah's relationship problems while they're on the mission. Meanwhile, Morgan finds himself in trouble when he lies to Jeff and Lester.
Chuck must use his relationship with Awesome to protect a visiting dictator, Premier Goya, who is the target of an assassination. While Awesome is excited about the prospect of being a spy, Chuck is more concerned about Awesome and Ellie's safety.
When Awesome is mistaken for a super spy by the evil Sydney Price, Chuck must become his handler and show him the spy ropes. While on a mission for The Ring, they meet the mysterious Daniel Shaw. Meanwhile, Morgan gets promoted to assistant manager and must deal with Jeff and Lester's latest hijinks.
Agent Daniel Shaw assigns Chuck to his first solo mission in Paris, ignoring Sarah and Casey's wishes. During the flight to France, Chuck befriends Hannah and flashes on another passenger - the imposing Hugo Panzer. Meanwhile, Casey helps Morgan battle Jeff and Lester for control of the Buy More.
Chuck juggles his two lives as he trains new Nerd Herder Hannah and gets his very own asset who is caught up with The Ring. Chuck thinks he can handle his asset all on his own but Sarah and Casey feel the need to intercede. Meanwhile, Awesome must lie to Ellie when she starts to ask questions about Chuck and Morgan, Jeff and Lester do some recon work to learn more about Hannah.
Chuck and Hannah unexpectedly become part of agent Daniel Shaw's latest mission. Much to Sarah's chagrin, she gets paired with Shaw, who seems to be trying to get close to her. Meanwhile, Morgan and Ellie continue their mission to get to the bottom of Chuck's secretive and strange behavior.
Chuck promises to cook dinner for Hannah, Ellie and Awesome but must first assume the identity of the world's most dangerous assassin for his latest mission. Meanwhile, Sarah is determined to keep her relationship with Shaw strictly professional.
Chuck feels like his life is falling apart when he can't flash and gets left behind for a mission. While Shaw, Sarah and Casey go on without him, Chuck finds himself in a sticky situation back at the base.
Casey carries out a side mission for his old commanding officer James Keller that leads to him committing treason. When Chuck learns the dark truth about Col. Keller, he and Sarah set out to break Casey out of jail and clear his name. Meanwhile, Awesome's plan to keep Ellie out of danger gets more difficult when she gets her dream fellowship.
Chuck learns that his latest solo mission will be a final test to see if he is ready to be a spy. Chuck needs to put everything he has learned into action to avoid going back to his old life while Sarah and Shaw observe his every move.
Chuck has his pick of the best CIA agents for an undercover operation, but he has only one girl in mind for the job; Sarah. Casey, Morgan and Awesome team up to help Chuck win her back.
Chuck, Sarah and Shaw reunite to find the Ring operative behind the death of Shaw's wife. Sarah has faith that Shaw is ready for the mission but Chuck is worried about his emotional stability. Meanwhile, Morgan considers leaving the Buy More.
While in Europe, Sarah and Chuck realize they're traveling on a train with Spanish spies. Even though they're all alone, they decide to take on these rogue agents. Of course, this impromptu mission doesn't go smoothly. Meanwhile, Beckman orders her newest "unlikely" spy team - John Casey and Morgan Grimes - to track down the missing couple.
Chuck and Sarah are assigned to train under Craig and Laura Turner, a married CIA team who, despite their impeccable record, hate one another. The Turners' stormy relationship forces Chuck and Sarah to wonder if they're doomed with the same fate. Meanwhile, Casey must train the newest member of the team - Morgan.
Chuck struggles with disturbing dreams and now he believes his most recent dream predicts danger for a visiting head of state. General Beckman, however, is unconvinced and assigns Chuck to meet with a CIA psychiatrist Dr. Leo Dreyfus. Meanwhile, Ellie gets surprising news and Anna returns to the Buy More to talk to Morgan.
After his last dream, Chuck asks Morgan to help him on a side mission. Their investigation becomes complicated when Stephen J. Bartowski returns and learns that Chuck downloaded the Intersect 2.0. Luckily, Chuck's father may be able to help his son.
The Ring is closing in on Chuck and Operation Bartowski. Fortunately, Chuck's dad Steven is working hard to save his son. Meanwhile, Casey must secretly protect his daughter from the Ring, and Big Mike receives some serious news about the Buy More.
Chuck and Morgan go on a rogue globe-spanning mission to find Chuck's mom. Meanwhile, Sarah and Casey follow a trail to Russia as they investigate the mysterious Volkoff Industries and its operative, Marco. Back at home, Ellie delivers big news to her family.
When Chuck and Sarah go undercover in Milan, Chuck realizes the "Achilles' Heel" in their relationship, but must set personal issues aside for the mission. Meanwhile, Morgan recognizes a fatal flaw that compromises the new Buy More. Elsewhere, Casey struggles to put down roots in Burbank.
Chuck and Sarah's romantic mission is cancelled with the arrival of Hugo Panzer and Heather Chandler. But Chuck grows more interested when the manipulative Heather claims to know a secret about his mom. Meanwhile, as Morgan prepares the Buy More for a huge video game release, he gets a surprise from Big Mike.
Chuck and Sarah work on becoming better communicators as they join Awesome and Ellie for a getaway to Costa Gravas. There, the gang is reunited with Generalissimo Goya who finds himself in a dangerous situation once again. Back at home, Morgan embarks on a forbidden romance that may put him at odds with Colonel John Casey.
When Colonel Casey's former team returns looking for him, Chuck must decide what he's willing to sacrifice in order to find his mom. Elsewhere, Morgan works up the nerve to reveal a potentially dangerous secret to Casey.
When Chuck, Sarah, Casey, and Morgan are tasked to stop Dr. Stanley Wheelright from releasing a nightmare-inducing toxin, they're also lead to question the allegiances of Chuck's mom. Meanwhile, Jeff and Lester use their unique sensibilities to celebrate Halloween at the Buy More, and Ellie and Awesome get a visit from Dr. Honey Woodcomb.
After their first real fight, Chuck avoids confronting Sarah by going on a rogue mission that leads him to his mom's MI-6 handler, Gregory Tuttle, and a mysterious Russian agent. Meanwhile, Ellie is on her own mission to uncover the Bartowski family's long-buried past.
Afraid that his latest setback is driving a wedge between him and Sarah, Chuck resolves to prove himself by going on a dangerous mission with the overeager Agent Rye. Meanwhile, Morgan and Casey scramble as the "Buy Morons" attempt to uncover the true identity of Greta.
Chuck, Sarah, Casey and Morgan venture into the jungles of Southeast Asia when The Belgian attempts to unravel the secrets of the Intersect. Meanwhile, Captain Awesome and Ellie try to decipher a secret left behind by her father.
It's the day after Thanksgiving and Chuck faces the most awkward of family reunions when mom comes over for dinner - along with the dangerous Alexei Volkoff. Back at the Buy More, Morgan deals with the busiest shopping day of the year as Jeff and Lester hatch their latest scheme.
When an assignment brings him to a French vineyard, Chuck juggles tracking down a nano-chip with trying to create the perfect romantic getaway for Sarah. Back at the Buy More, Lester comes to Big Mike for his own romantic problems.
Sarah takes dangerous measures to help Mary Bartowski bring down Alexei Volkoff, as Chuck worries that she may be getting in too deep. Sarah, though, must enlist the help of Chuck, Morgan and Casey to complete her undercover mission. Meanwhile, Ellie and Awesome are at odds over what to name the baby.
As Sarah works to free Chuck's mom, Chuck and Morgan embark on their own mission to take down Alexei Volkoff. Meanwhile, Casey bonds with his daughter, Alex, while Ellie tries to ease Awesome's anxieties over fatherhood.
In need of an exciting new mission, Chuck, Sarah and Casey are sent to Morocco to rescue Roan Montgomery. Meanwhile, Chuck and Sarah are at odds over their future plans. Back at home, Morgan prepares to meet Alex's mom, as Mary bonds with her family.
Chuck surprises Sarah with her old spy team, The C.A.T. Squad, leading to a mission in Rio. As The C.A.T. Squad works to settle a score with Augusto Gaez, old secrets and grudges come to light. Back at the Buy More, Morgan fends off the advances of Carina, a former flame and frisky member of The C.A.T Squad.
Valentine's Day is interrupted when Chuck and the team are sent on a mission to England to protect a reclusive young heiress, Vivian McArthur. Meanwhile, Casey gets an offer from the mysterious Jane Bentley. Back at home, Ellie and Awesome find an unlikely solution to a parenting problem, as Morgan ponders a big move.
Chuck pushes Vivian McArthur to get in touch with her inner villain for a mission. Elsewhere, Sarah tries to get in touch with her inner bride as wedding plans ramp up. Meanwhile, Morgan's search for a new roommate takes an unexpected turn.
Chuck and Sarah investigate when they suspect that Casey is carrying out private missions. Meanwhile, Chuck fears that the CIA's seemingly-perfect new operatives will render him obsolete. Elsewhere, Morgan settles in with a new roommate, and Awesome panics when Ellie embarks on a potentially dangerous line of research.
Chuck is put in charge of a top-priority mission, but his leadership skills are pushed to the limit when there is a murder in Castle. Meanwhile, Awesome takes on a mission of his own when Ellie finds an alarming new hobby. Elsewhere, Morgan's leadership is also tested when his Buy More troops wage war against Large Mart.
Bad day gets worse when Sarah throws Chuck a surprising relationship curveball as the CIA orders Vivian Volkoff assassinated. In order to prove Vivian's innocence, Chuck must put his trust in a dangerous ally her father Alexei Volkoff. Meanwhile, Ellie suspects that her mother is interfering with the search into her father's past.
When Chuck and Sarah get conned out of their wedding money, there is only one man they can turn to for help -- Sarah's conman father, Jack Burton. Meanwhile, Morgan pressures Casey to face Alex's mother.
Chuck and Sarah put aside spy work to have a weekend of debauchery, but Awesome's plans for Chuck's big night don't go quite as expected. Meanwhile, Ellie's investigation into her father's computer leads to a life-changing discovery.
Chuck and Sarah's wedding prep includes one final detail: ensuring that the mother-of-the-groom makes it to the ceremony alive. Meanwhile, Morgan's responsibilities as Best Man include his most dangerous mission yet, as he faces Vivian Volkoff. Elsewhere, Ellie tends to the last details of the rehearsal dinner and seeks help from an unlikely source.
Before he can kiss the bride, Chuck must enlist his wedding party to take down Vivian Volkoff and stop her from destroying the big day. When he turns to Alexei Volkoff for help, the CIA sends its toughest agent, Clyde Decker, to stop them.
Without the Intersect in his head or the support of the CIA, the world of espionage is a much more dangerous place for Chuck Bartowski and his team of freelance spies. To start, Carmichael Industries takes on a slick, rich thief named Jean Claude, and a conniving investor, Roger Bale, who has stolen money from some of the world's most dangerous people. Meanwhile, Morgan helps Chuck with a special surprise for Sarah. Back in the Buy More, Jeff and Lester have taken things to another level with their latest scheme.
As the team takes on a missing persons case, Chuck and company struggle to establish themselves as Carmichael Industries in the face of a rival security firm led by the tough and efficient Gertrude Verbanski. Meanwhile, Morgan continues to adjust to the Intersect while Chuck adjusts to being his handler. Also, the Buy More finds an unlikely spokesperson to help drum up business.
As the team is tasked with finding one of the CIAs most wanted, Chuck fears that the Intersect may be going to Morgan's head. Meanwhile Sarah helps Casey navigate his relationship with Gertrude. Elsewhere, Captain Awesome makes a startling revelation about Jeff and Lester.
Chuck and Sarah go undercover at a Buy More convention to hunt down an assassin whose mission is to take down the new Intersect. Meanwhile, Morgan must deal with the consequences of having the Intersect. At the Buy More, Jeff begins to show a very different side of himself.
Mission to track down a computer super virus leads Chuck to return to his roots as a hacker -- and to call on his biggest competition, Gertrude Verbanksi, for help. Elsewhere, a new Buy More employee complicates Jeff and Lester's friendship.
Chuck and Sarah race against time to take down a dangerous computer virus, pitting them against Robyn Cunnings, a ruthless spy who will stop at nothing to get what she needs. Meanwhile, Ellie and Awesome's date night takes a dangerous turn and Morgan is sent on a special mission to recover Chuck's P.A.N.T.S.
Chuck and Sarah discover who's behind the plot to destroy Carmichael Industries. Meanwhile, Ellie's plans for a perfect Christmas begin to come apart. At the Buy More, Morgan and the gang must fend off angry customers as a computer virus threatens to ruin Christmas.
Sarah is forced to confront a secret from her past and feels she must do so alone, while Chuck urges her to let him help. When Sarah encounters her original handler, Kieran Ryker, she fears that he will harm those closest to her, including her mom.
While Chuck and Sarah contemplate the next step for Carmichael Industries, Casey's forbidden love, Gertrude Verbanski, walks back into his life with a questionable mission in South Beach. Meanwhile, Jeff's enhanced intelligence leads he and Lester to suspect that something unusual may be happening at the Buy More.
As Chuck and Sarah try to realize a new, safer future, Morgan's past as the Intersect sends them to Vail on one last mission, where they enlist the help of an unlikely source -- the legendary Bo Derek. Elsewhere, Jeff and Lester continue their own spy mission.
When a mission in Japan becomes a hostage situation, Sarah and Chuck must face the merciless Nicholas Quinn aboard a speeding Japanese bullet train. Meanwhile, the mission leaves Casey with an impossible decision.
After a harrowing mission, Sarah returns to Chuck with a huge secret. Meanwhile, Ellie and Awesome are presented with a new opportunity that could change their lives.
Chuck enlists his family, friend and some unexpected allies as he races to stop Nicholas Quinn from destroying everything Chuck has built over the past five years.